Have you come to the Fork in the Road? Would you like to see it in person? Let us know in the comments! Check out this delightfully offbeat attraction in Kentucky in this video:įor more information on this roadside attraction in Kentucky and other features of Franklin, visit the Simpson County Tourism website. The Fork in the Road in Franklin isn’t the flashiest of attractions, but it’s worthy of some backroad exploring in our wonderful state. maybe some other utensils).īring a camera, a sense of humor, and an appreciation for all things quirky and track down this roadside attraction in Kentucky. Perhaps they should be, because this one is fun and interesting (and we wish there were more like it. Kentucky is known for a lot of things, but its oddities aren't one of them. add any of the following: chicken (roasted, grilled, double toasted, blackened or parmesan crusted) 4. Where else will you see a giant fork, quite literally in the road? Nowhere but here, of course. ![]() 2015 58(6):1090–1100.Franklin is much more than a drive through town and has quite a bit to offer. HLTF’s ancient HIRAN domain binds 3’ DNA ends to drive replication fork reversal. Kile A.C., Chavez D.A., Bacal J., Eldirany S., Korzhnev D.M., Bezsonova I., Eichman B.F., Cimprich K.A. Replication fork slowing and reversal upon DNA damage require PCNA polyubiquitination and ZRANB3 DNA translocase activity. The Fork Team, our guests and the Fork experience are priorities. Vujanovic M., Krietsch J., Raso M.C., Terraneo N., Zellweger R., Schmid J.A., Taglialatela A., Huang J.W., Holland C.L., Zwicky K., Herrador R., Jacobs H., Cortez D., Ciccia A., Penengo L., Lopes M. The Fork in the Road strives to consistently deliver an exceptional experience to each guest through high-quality food, beverage, and service in a great atmosphere. Replication fork reversal in eukaryotes: from dead end to dynamic response. Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells. Zellweger R., Dalcher D., Mutreja K., Berti M., Schmid J.A., Herrador R., Vindigni A., Lopes M. Causes and consequences of replication stress. Here we discuss how fork protection arises and how its differences with HR give insights into the differing contexts of these two pathways.īRCA1 BRCA2 Fork reversal Homologous recombination RAD51 Replication fork protection.Ĭopyright © 2020 The Authors. Protection of stalled forks not only requires separate functions of a number of recombination proteins, but also utilises nucleases important for the resection steps of HR in alternative ways. Thousands of new images every day Completely Free to Use High-quality videos and. A Fork in the Road Meet the key players who bring Georgia Grown products to the Peach State and beyond. Fork in the Road FORK IN THE ROAD: Junction City’s ‘Bella’s Italian Restaurant’ has served made-from-scratch for over a decade. Download and use 70000+ Fork In The Road stock photos for free. ![]() However, despite the similarities of these pathways, several lines of evidence indicate that fork protection is not simply analogous to the RAD51 loading step of HR. The restaurant is located at 311 E Bertrand Ave., in St. Proteins that promote the recruitment, loading and stabilisation of RAD51 onto single-stranded DNA for homology search and strand exchange in homologous recombination (HR) repair and inter-strand cross-link repair also act to set up RAD51-mediated protection of nascent DNA at stalled replication forks. In such a structure the annealed nascent strand is thought to resemble a DNA double-strand break and remodelled forks are vulnerable to nuclease attack by MRE11 and DNA2. In response to replication hindrances, DNA replication forks frequently stall and are remodelled into a four-way junction.
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